Synthesis and characterization of new platinum (II) complexes with cyclic iminoether-type ligands having the azomethine group out of cycle

N Margiotta, C Pacifico, T Saltarella, G Natile… - Inorganica Chimica …, 2022 - Elsevier
… with significant antitumor activity and, being their DNA-binding … , trans-[PtCl 2 (E-iminoether)
2 ] (trans-EE), trans-[PtCl 2 (NH 3 … The first transformation led to formation of an intermediate …

DNA–Protein Cross-links: Formation, Genotoxicity and Repair

AK Basu, C Campbell, NY Tretyakova - 2020 - books.rsc.org
… by exposure to various anti-tumor drugs, transition metals, and … -linked to DNA via cisplatin
or trans-[PtCl 2 (E-iminoether) 2 ]. … to antitumor drugs and formed at epigenetic DNA marks, …

[PDF][PDF] Chapter-2 Platinum and its complexes as Anticancer Agents Author name: Dhananjay Das

D Das - CHEMICAL SCIENCES, 2020 - researchgate.net
… therapy also contains some side effects such as diarrhea, liver … anticancer drug was born
in 16th November 1926 and died in 8th … Different types anticancer agents of Pt (II) and Pt (IV) …

Fabricating nanoparticles co-loaded with survivin siRNA and Pt (IV) prodrug for the treatment of platinum-resistant lung cancer

S Ma, X Li, M Ran, M Ji, J Gou, T Yin, H He… - International journal of …, 2021 - Elsevier
… [II]), as one of the principal anticancer chemotherapeutic … obtained on a JEM-2100 transmission
electron microscope at an … (II) in the reducing environment of cells and binding to DNA

Synthesis and polymerase bypass studies of DNA-peptide and DNA-protein conjugates

SS Pujari, N Tretyakova - Methods in enzymology, 2021 - Elsevier
… challenges to cell survival by blocking DNA replication, transcription, and repair. However, …
guanine adducts generated by antitumor nitrogen mustards, platinum compounds, 1,2,3,4-…